SEMA3B Gene Summary [Human]
The protein encoded by this gene belongs to the class-3 semaphorin/collapsin family, whose members function in growth cone guidance during neuronal development. This family member inhibits axonal extension and has been shown to act as a tumor suppressor by inducing apoptosis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Details
| Type | Protein Coding |
| Official Symbol | SEMA3B |
| Official Name | semaphorin 3B [Source:HGNC Symbol;Acc:HGNC:10724] |
| Ensembl ID | ENSG00000012171 |
| Bio databases IDs | |
| Aliases | semaphorin 3B |
| Synonyms | LUCA-1, SemA, SEMA5, SEMAA, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B, semaphorin 3B, semaV |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SEMA3B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- semaphorin domain
- chemorepellant
- immunoglobulin domain
- protein binding
- furin cleavage site
- Sema domain
- The Sema domain, a protein interacting module, of semaphorins and plexins
Pathways
Biological processes and signaling networks where the SEMA3B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- proliferative diabetic retinopathy
- peripheral arterial disease
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- metastasis
- acute myeloid leukemia
- androgenic alopecia
- papillary thyroid carcinoma
role in cell
- proliferation
- apoptosis
- quantity
- binding
- phosphorylation in
- growth
- colony formation
- signaling
- disassembly
- contact repulsion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SEMA3B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative chemotaxis
- neural crest cell migration
- cell-cell signaling
- axon guidance
- positive regulation of cell migration
- semaphorin-plexin signaling pathway
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- chemorepellent activity
- semaphorin receptor binding