ADCY3 Gene Summary [Human]

This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

Details

Type
Protein Coding
Official Symbol
ADCY3
Official Name
adenylate cyclase 3 [Source:HGNC Symbol;Acc:HGNC:234]
Ensembl ID
ENSG00000138031
Bio databases IDs NCBI: 109 Ensembl: ENSG00000138031
Aliases adenylate cyclase 3
Synonyms AC3, AC-III, adenylate cyclase 3, BMIQ19, mKIAA0511
Species
Human, Homo sapiens
OrthologiesRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ADCY3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • adenylate cyclase
  • calcium/calmodulin-responsive adenylate cyclase
  • Class III nucleotidyl cyclases
  • enzyme
  • Adenylyl- / guanylyl cyclase, catalytic domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • ulcerative colitis
  • type 2 diabetic obesity
  • obesity
  • Crohn disease
  • morbid obesity
  • inflammatory bowel disease
  • susceptibility to obesity type BMIQ19
  • breast carcinoma
  • monogenic obesity
  • multiple sclerosis
regulated by
  • beta-estradiol
  • IL2
  • GW3965
  • EBF1
  • tetradecanoylphorbol acetate
  • medroxyprogesterone acetate
  • 8-bromo-cAMP
  • MEK
  • KRAS
  • AKT
regulates
  • reactive oxygen species
  • cyclic AMP
  • MMP2
role in cell
  • proliferation
  • migration
  • formation
  • invasion
  • growth
  • response by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • caveolae fraction
  • Cytoplasm
  • cilia
  • perinuclear region
  • cellular membrane
  • Nucleus
  • Golgi Apparatus
  • apical cytoplasm
  • sperm midpiece
  • acrosome
  • perikaryon
  • dendrites
  • plasma

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human ADCY3 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • cAMP biosynthetic process
  • sperm motility
  • acrosome reaction
  • signal transduction
  • sensory perception of smell
  • olfactory learning
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway
  • single fertilization
  • intracellular signal transduction

Cellular Component

Where in the cell the gene product is active
  • cytoplasm
  • membrane
  • cilium
  • Golgi apparatus
  • cilium membrane
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • ATP binding
  • calmodulin binding
  • metal ion binding
  • adenylate cyclase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.