DNTTIP2 Gene Summary [Human]
This gene is thought to be involved in chromatin remodeling and gene transcription. The encoded nuclear protein binds to and enhances the transcriptional activity of the estrogen receptor alpha, and also interacts with terminal deoxynucleotidyltransferase. The expression profile of this gene is a potential biomarker for chronic obstructive pulmonary disease. [provided by RefSeq, Dec 2010]
Details
| Type | Protein Coding |
| Official Symbol | DNTTIP2 |
| Official Name | deoxynucleotidyltransferase terminal interacting protein 2 [Source:HGNC Symbol;Acc:HGNC:24013] |
| Ensembl ID | ENSG00000067334 |
| Bio databases IDs | |
| Aliases | deoxynucleotidyltransferase terminal interacting protein 2, acidic 82 kDa protein mRNA |
| Synonyms | 4930588M11Rik, deoxynucleotidyltransferase terminal interacting protein 2, deoxynucleotidyltransferase, terminal, interacting protein 2, ERBP, FCF2, HSU15552, LPTS-RP2, RGD1309084, TdIF2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DNTTIP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Fcf2 pre-rRNA processing
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- chronic kidney disease
- nonsyndromic cleft lip and palate
- uterine leiomyoma
- leiomyomatosis
role in cell
- expression in
- G1 phase
- processing in
- G2 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- pre-ribosome
- chromosome
- nucleoplasm
- nucleoli
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DNTTIP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ribosomal small subunit biogenesis
- RNA processing
Cellular Component
Where in the cell the gene product is active
- small-subunit processome
- chromosome
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding