TPD52 Gene Summary [Human]
Enables calcium ion binding activity and protein homodimerization activity. Involved in B cell differentiation. Located in endoplasmic reticulum and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TPD52 |
| Official Name | tumor protein D52 [Source:HGNC Symbol;Acc:HGNC:12005] |
| Ensembl ID | ENSG00000076554 |
| Bio databases IDs | |
| Aliases | tumor protein D52 |
| Synonyms | Crhsp-28, D52, hD52, mD52, N8L, PC-1, PRLZ, tumor protein D52, tumour protein D52 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TPD52 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tumour protein D52 family
- calcium ion binding
- protein homodimerization
- coiled-coil domain
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- neoplasia
- prostate cancer
- lung cancer
- rheumatoid arthritis
- Huntington disease
- small cell lung cancer
- organismal death
- ductal breast carcinoma
role in cell
- expression in
- growth
- cell death
- invasion by
- apoptosis
- phosphorylation in
- proliferation
- migration
- colony formation
- tumorigenicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- interchromatin granule cluster fractions
- microsomal fraction
- soluble fraction
- intracellular nanovesicle
- pH resistant lipid raft fraction
- glutaminergic synapse
- perinuclear region
- Endoplasmic Reticulum
- apical cytoplasm
- basal cytoplasm
- endosomal compartment
- synapse
- smooth microsomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TPD52 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- secretion
- B cell differentiation
- anatomical structure morphogenesis
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytoplasm
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding
- calcium ion binding