ADCYAP1R1 Gene Summary [Human]

This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010]

Details

Type
Protein Coding
Official Symbol
ADCYAP1R1
Official Name
ADCYAP receptor type I [Source:HGNC Symbol;Acc:HGNC:242]
Ensembl ID
ENSG00000078549
Bio databases IDs NCBI: 117 Ensembl: ENSG00000078549
Aliases ADCYAP receptor type I, PACAP receptor 1, pituitary adenylate cyclase-activating polypeptide type 1 receptor
Synonyms 2900024I10RIK, ADCYAP receptor type I, adenylate cyclase activating polypeptide 1 receptor 1, PAC1, PAC1-R, PAC1 receptor, PACAP1-R, PACAPR, PACAP-R1, PACAP-R1A, PACAPRI, Pvr1
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ADCYAP1R1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • G-protein coupled receptor
  • Hormone receptor domain
  • 7 transmembrane receptor (Secretin family)
  • neuropeptide binding
  • signaling receptor activity
  • adenylate cyclase binding
  • enzyme binding
  • protein binding
  • seven-transmembrane G protein-coupled receptor superfamily
  • pituitary adenylate cyclase activating protein receptor
  • vasoactive intestinal polypeptide receptor

Pathways

Biological processes and signaling networks where the ADCYAP1R1 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • hyperinsulinism
  • side effect
  • hemangioma
  • angiomatosis
  • hydrocephalus
  • impaired glucose tolerance
  • diabetic nephropathy
  • apnea
  • cluster headache
  • infection by bacteria
regulated by
regulates
role in cell
  • activation in
  • expression in
  • migration
  • proliferation
  • apoptosis
  • depolarization
  • survival
  • disruption
  • long-term potentiation
  • morphology

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • intracellular membrane-bounded organelle
  • cell surface
  • cellular membrane
  • endosomes
  • caveolae
  • Golgi membrane
  • tight junctions
  • perikaryon

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human ADCYAP1R1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • spermatogenesis
  • development of primary female sexual characteristics
  • cell surface receptor signaling pathway
  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway
  • positive regulation of cAMP-mediated signaling
  • response to xenobiotic stimulus
  • positive regulation of inositol phosphate biosynthetic process
  • response to ethanol
  • positive regulation of small GTPase mediated signal transduction
  • response to estradiol stimulus
  • multicellular organismal response to stress
  • cell differentiation
  • positive regulation of calcium ion transport into cytosol
  • cAMP-mediated signaling

Cellular Component

Where in the cell the gene product is active
  • caveola
  • tight junction
  • endosome
  • intracellular membrane-bounded organelle
  • receptor complex
  • plasma membrane
  • cell surface

Molecular Function

What the gene product does at the molecular level
  • neuropeptide binding
  • vasoactive intestinal polypeptide receptor activity
  • G-protein coupled peptide receptor activity
  • protein binding
  • signaling receptor activity
  • small GTPase binding
  • adenylate cyclase binding
  • peptide hormone binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.