Adcyap1r1 Gene Summary [Rat]
Enables adenylate cyclase binding activity; neuropeptide binding activity; and small GTPase binding activity. Involved in several processes, including cAMP/PKA signal transduction; positive regulation of inositol phosphate biosynthetic process; and positive regulation of intracellular signal transduction. Located in several cellular components, including bicellular tight junction; caveola; and cell surface. Biomarker of cystitis. Orthologous to human ADCYAP1R1 (ADCYAP receptor type I). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adcyap1r1 |
| Official Name | ADCYAP receptor type I [Source:RGD Symbol;Acc:2038] |
| Ensembl ID | ENSRNOG00000012098 |
| Bio databases IDs | |
| Aliases | ADCYAP receptor type I |
| Synonyms | 2900024I10RIK, ADCYAP receptor type I, adenylate cyclase activating polypeptide 1 receptor 1, PAC1, PAC1-R, PAC1 receptor, PACAP1-R, PACAPR, PACAP-R1, PACAP-R1A, PACAPRI, Pvr1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adcyap1r1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Hormone receptor domain
- 7 transmembrane receptor (Secretin family)
- neuropeptide binding
- signaling receptor activity
- adenylate cyclase binding
- enzyme binding
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- pituitary adenylate cyclase activating protein receptor
- vasoactive intestinal polypeptide receptor
Pathways
Biological processes and signaling networks where the Adcyap1r1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperinsulinism
- side effect
- hemangioma
- angiomatosis
- hydrocephalus
- impaired glucose tolerance
- diabetic nephropathy
- apnea
- cluster headache
- infection by bacteria
role in cell
- activation in
- expression in
- migration
- proliferation
- apoptosis
- depolarization
- survival
- disruption
- long-term potentiation
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cell surface
- cellular membrane
- endosomes
- caveolae
- Golgi membrane
- tight junctions
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adcyap1r1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatogenesis
- development of primary female sexual characteristics
- cell surface receptor signaling pathway
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- positive regulation of cAMP-mediated signaling
- response to xenobiotic stimulus
- positive regulation of inositol phosphate biosynthetic process
- response to ethanol
- positive regulation of small GTPase mediated signal transduction
- response to estradiol stimulus
- multicellular organismal response to stress
- cell differentiation
- positive regulation of calcium ion transport into cytosol
- cAMP-mediated signaling
Cellular Component
Where in the cell the gene product is active
- caveola
- tight junction
- endosome
- intracellular membrane-bounded organelle
- receptor complex
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- neuropeptide binding
- vasoactive intestinal polypeptide receptor activity
- G-protein coupled peptide receptor activity
- protein binding
- signaling receptor activity
- small GTPase binding
- adenylate cyclase binding
- peptide hormone binding