PPIL2 Gene Summary [Human]
This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]
Details
| Type | Retained Intron |
| Official Symbol | PPIL2 |
| Official Name | peptidylprolyl isomerase like 2 [Source:HGNC Symbol;Acc:HGNC:9261] |
| Ensembl ID | ENSG00000100023 |
| Bio databases IDs | |
| Aliases | peptidylprolyl isomerase like 2, U-box domain containing 7, peptidyl-prolyl cis-trans isomerase-like 2 |
| Synonyms | 0610009L05Rik, 1700016N17Rik, 4921520K19Rik, 4930511F14Rik, C130078A06Rik, CYC4, CYP60, hCyP-60, peptidylprolyl isomerase (cyclophilin)-like 2, peptidylprolyl isomerase like 2, UBOX7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPIL2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidylprolyl isomerase
- Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
- cyclophilin
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Modified RING finger domain
- ubiquitin-protein transferase activity
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- Golgi lumen
- Cytoplasm
- Plasma Membrane
- spliceosomes
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPIL2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- protein polyubiquitination
- mRNA processing
- protein folding
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- nucleus
- catalytic step 2 spliceosome
- cytoplasm
- Golgi lumen
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- cyclosporin A binding
- peptidyl-prolyl cis-trans isomerase activity
- protein binding
- ubiquitin-ubiquitin ligase activity