MICALL1 Gene Summary [Human]
Enables identical protein binding activity; phosphatidic acid binding activity; and small GTPase binding activity. Involved in several processes, including plasma membrane tubulation; protein localization to endosome; and slow endocytic recycling. Located in late endosome and recycling endosome membrane. Is extrinsic component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MICALL1 |
| Official Name | MICAL like 1 [Source:HGNC Symbol;Acc:HGNC:29804] |
| Ensembl ID | ENSG00000100139 |
| Bio databases IDs | |
| Aliases | MICAL like 1, molecule interacting with Rab13 |
| Synonyms | D15Mit260, D15N2e, EST573322, EST820961, MICAL-like 1, microtubule associated monooxygenase, calponin and LIM domain containing -like 1, MIRAB13, mKIAA1668, RGD1305415 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MICALL1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- Calponin homology domain
- binding protein
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- Bivalent Mical/EHBP Rab binding domain
- protein binding activity, bridging
- NPF motif
- calponin homology (CH) domain superfamily
- enzyme binding
- protein binding
- identical protein binding
- cytoskeletal adaptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cilia
- centriole
- endosomal membrane
- late endosomes
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MICALL1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane tubulation
- neuron projection development
- protein localization in endosome
- protein transport
- slow endocytic recycling
- endocytosis
- receptor-mediated endocytosis
- protein targeting to membrane
- endocytic recycling
Cellular Component
Where in the cell the gene product is active
- late endosome membrane
- early endosome
- trans-Golgi network
- external side of endosome membrane
- late endosome
- recycling endosome membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- metal ion binding
- cadherin binding
- small GTPase binding
- phosphatidic acid binding