KIF3B Gene Summary [Human]
The protein encoded by this gene acts as a heterodimer with kinesin family member 3A to aid in chromosome movement during mitosis and meiosis. The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous organelles. This protein and kinesin family member 3A form the kinesin II subfamily of the kinesin superfamily. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | KIF3B |
| Official Name | kinesin family member 3B [Source:HGNC Symbol;Acc:HGNC:6320] |
| Ensembl ID | ENSG00000101350 |
| Bio databases IDs | |
| Aliases | kinesin family member 3B |
| Synonyms | FLA8, HH0048, Kif3b predicted, kinesin family member 3B, KLP-11, mKIAA0359, OTSC12, RP89 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KIF3B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Kinesin motor, catalytic domain
- microtubule binding
- binding protein
- Myosin and Kinesin motor domain
- Kinesin motor domain
- enzyme binding
- plus-end-directed kinesin ATPase
- protein binding
- motor domain
- microtubule motor protein
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- exencephaly
- insomnia
- retinitis pigmentosa type 89
- oligozoospermia
role in cell
- binding in
- expression in
- sprouting
- organization
- long-term potentiation
- long term synaptic depression
- trafficking
- growth
- abnormal morphology
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- microtubule cytoskeleton
- ciliary tip
- cilia
- postsynaptic region
- vesicles
- centrosome
- midbody
- cytosol
- apical vesicles
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KIF3B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- plus-end-directed vesicle transport along microtubule
- vesicle-mediated transport
- anterograde axon cargo transport
- intraflagellar transport
- cilium morphogenesis
- mitotic spindle organization
- mitotic centrosome separation
- microtubule-based movement
- determination of left/right symmetry
- positive regulation of cytokinesis
- spindle assembly involved in mitosis
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- kinesin II complex
- kinesin complex
- plus-end kinesin complex
- microtubule
- dendrite
- spindle microtubule
- centrosome
- extracellular vesicular exosome
- dendritic spine
- dendrite cytoplasm
- membrane
- cilium
- cytosol
- midbody
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- microtubule motor activity
- protein binding
- small GTPase binding
- plus-end-directed microtubule motor activity
- microtubule binding