NKAP Gene Summary [Human]
This gene encodes a protein that is involved in the activation of the ubiquitous transcription factor NF-kappaB. This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it thereby acts as a transcriptional repressor of Notch target genes. It is also required for alphabeta T cell development. A related pseudogene has been identified on chromosome X, while a related and intronless retrocopy, which has an intact CDS and may be functional, is located on chromosome 6. [provided by RefSeq, May 2010]
Details
| Type | Protein Coding |
| Official Symbol | NKAP |
| Official Name | NFKB activating protein [Source:HGNC Symbol;Acc:HGNC:29873] |
| Ensembl ID | ENSG00000101882 |
| Bio databases IDs | |
| Aliases | NFKB activating protein, NF kappaB activating protein |
| Synonyms | 2610020O08RIK, MRXSHD, NFKB activating protein |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NKAP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- NF-kappa-B-activating protein C-terminal domain
- mRNA binding
- chromatin binding
- protein binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Hackman-Di Donato type syndromic X-linked mental retardation
role in cell
- expression in
- proliferation
- cell death
- binding in
- differentiation
- binding
- erastin sensitivity
- iFSP1 sensitivity
- Clathrin mediated endocytosis by
- erastin resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NKAP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- Notch signaling pathway
- negative regulation of transcription, DNA-dependent
- T cell differentiation in thymus
- somatic stem cell maintenance
- hemopoietic stem cell proliferation
- granulocyte differentiation
- positive regulation of alpha-beta T cell differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- protein binding
- RNA binding
- mRNA binding
- chromatin binding
- binding, bridging