IL27RA Gene Summary [Human]
In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | IL27RA |
| Official Name | interleukin 27 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:17290] |
| Ensembl ID | ENSG00000104998 |
| Bio databases IDs | |
| Aliases | interleukin 27 receptor subunit alpha, T-cell cytokine receptor type 1 |
| Synonyms | CRL1, IL-27R, IL-27R-alpha, IL-27R-α, interleukin 27 receptor, alpha, interleukin 27 receptor subunit alpha, interleukin 27 receptor subunit α, interleukin 27 receptor, α, TCCR, WSX-1, zcytor1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IL27RA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- interleukin-27 receptor
- cytoplasmic domain
- FN3
- protein binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the IL27RA gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver neoplasia
- epithelial neoplasia
- liver cancer
- digestive system cancer
- abdominal cancer
- cancer
- epithelial cancer
- infection
- colitis
- weight loss
role in cell
- expression in
- differentiation
- proliferation
- apoptosis
- quantity
- activation
- number
- activation in
- binding
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Extracellular Space
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IL27RA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell surface receptor signaling pathway
- negative regulation of neuron apoptotic process
- negative regulation of interleukin-6 production
- negative regulation of T-helper 17 type immune response
- immune response
- regulation of isotype switching to IgG isotypes
- cytokine-mediated signaling pathway
- negative regulation of T cell extravasation
- positive regulation of interferon-gamma production
- positive regulation of T-helper 1 type immune response
- negative regulation of type 2 immune response
- negative regulation of interleukin-17 production
- interleukin-27-mediated signaling pathway
- negative regulation of tumor necrosis factor production
- defense response to Gram-positive bacterium
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- interleukin-27 receptor activity
- protein binding
- transmembrane signaling receptor activity
- cytokine binding