RAB11FIP2 Gene Summary [Human]
Enables protein homodimerization activity and protein kinase binding activity. Involved in several processes, including TRAM-dependent toll-like receptor 4 signaling pathway; phagocytosis; and positive regulation of GTPase activity. Located in endosome; nucleoplasm; and phagocytic cup. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RAB11FIP2 |
| Official Name | RAB11 family interacting protein 2 [Source:HGNC Symbol;Acc:HGNC:29152] |
| Ensembl ID | ENSG00000107560 |
| Bio databases IDs | |
| Aliases | RAB11 family interacting protein 2 |
| Synonyms | 4930470G04RIK, A830046J09RIK, AW558126, LOC108349712, Nrip11, RAB11 family interacting protein 2, RAB11 family interacting protein 2 (class I), RGD1308538 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RAB11FIP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- Rab11 binding domain
- RNA recognition motif
- FIP domain
- protein homodimerization
- protein binding
- Protein kinase C conserved region 2 (CalB)
- identical protein binding
- C2 domain
Pathways
Biological processes and signaling networks where the RAB11FIP2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- tubular endosomal network
- cytoplasmic vesicle membrane
- intracellular membrane-bounded organelle
- perinuclear region
- Plasma Membrane
- endosomes
- vesicles
- nucleoplasm
- recycling endosomes
- early endosomes
- cytoplasmic vesicles
- phagocytic cups
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RAB11FIP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- insulin secretion involved in cellular response to glucose stimulus
- regulated secretory pathway
- phagocytosis
- establishment of cell polarity
- TRAM-dependent toll-like receptor 4 signaling pathway
- positive regulation of GTPase activity
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle membrane
- endosome
- intracellular membrane-bounded organelle
- recycling endosome membrane
- cell projection
- phagocytic cup
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- identical protein binding
- protein binding
- protein homodimerization activity
- small GTPase binding