IL26 Gene Summary [Human]
This gene was identified by its overexpression specifically in herpesvirus samimiri-transformed T cells. The encoded protein is a member of the IL10 family of cytokines. It is a secreted protein and may function as a homodimer. This protein is thought to contribute to the transformed phenotype of T cells after infection by herpesvirus samimiri. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | IL26 |
| Official Name | interleukin 26 [Source:HGNC Symbol;Acc:HGNC:17119] |
| Ensembl ID | ENSG00000111536 |
| Bio databases IDs | |
| Aliases | interleukin 26 |
| Synonyms | AK155, interleukin 26 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IL26 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytokine
Pathways
Biological processes and signaling networks where the IL26 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- neoplastic cell transformation
- pruritus
- diabetic retinopathy
- psoriasis
- autoantibody associated vasculitis
- crescentic glomerulonephritis
role in cell
- proliferation
- production in
- adsorption in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IL26 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- positive regulation of ERK1 and ERK2 cascade
- negative regulation of epithelial cell proliferation
- cell-cell signaling
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of cytokine production
- positive regulation of stress-activated MAPK cascade
- positive regulation of protein kinase B signaling cascade
- positive regulation of JAK-STAT cascade
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytosol
- extracellular region
Molecular Function
What the gene product does at the molecular level
- cytokine activity