TIMELESS Gene Summary [Human]
The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. [provided by RefSeq, Feb 2014]
Details
| Type | Protein Coding |
| Official Symbol | TIMELESS |
| Official Name | timeless circadian regulator [Source:HGNC Symbol;Acc:HGNC:11813] |
| Ensembl ID | ENSG00000111602 |
| Bio databases IDs | |
| Aliases | timeless circadian regulator, Tof1 homolog (S. cerevisiae), timeless circadian clock 1 |
| Synonyms | Debt69, FASPS4, hTIM, LOC100504989, rTIM, rTLP, TIM, TIM1, TIMELESS1, timeless circadian clock 1, timeless circadian regulator |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TIMELESS often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Timeless protein
- Timeless PAB domain
- protein binding
- enzyme activator activity
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- oral squamous cell carcinoma
- lung adenocarcinoma
- squamous cell cancer of the oral cavity
- metastasis
- organismal death
- lung adenocarcinoma formation
- familial advanced sleep phase syndrome type 4
- ocular hypertension
role in cell
- growth
- apoptosis
- expression in
- production in
- migration
- proliferation
- formation
- formation in
- cell viability
- DNA damage response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TIMELESS gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- cellular response to cisplatin
- detection of abiotic stimulus
- replication fork arrest
- branching morphogenesis of a tube
- circadian rhythm
- regulation of circadian rhythm
- response to DNA damage stimulus
- regulation of cell proliferation
- cell division
- DNA replication checkpoint
- negative regulation of transcription, DNA-dependent
- morphogenesis of an epithelium
- cellular response to hydroxyurea
- positive regulation of double-strand break repair
- lung development
Cellular Component
Where in the cell the gene product is active
- nucleus
- site of double-strand break
- replication fork protection complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- identical protein binding
- protein binding