CCNK Gene Summary [Human]
The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | CCNK |
| Official Name | cyclin K [Source:HGNC Symbol;Acc:HGNC:1596] |
| Ensembl ID | ENSG00000090061 |
| Bio databases IDs | |
| Aliases | cyclin K |
| Synonyms | CPR4, CycK, cyclin K, IDDHDF |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CCNK often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- cyclin-dependent protein kinase
- protein serine/threonine kinase
- [RNA-polymerase]-subunit kinase
- protein kinase binding
- Cyclin box fold superfamily
- domain present in cyclins, TFIIB and Retinoblastoma
- protein binding
Pathways
Biological processes and signaling networks where the CCNK gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- intellectual developmental disorder with hypertelorism and distinctive facies
- endometriosis
role in cell
- expression in
- growth
- phosphorylation in
- differentiation
- replication in
- survival
- cell cycle progression
- DNA damage response
- downregulation in
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CCNK gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- cell division
- transcription from RNA polymerase II promoter
- response to DNA damage stimulus
- regulation of signal transduction
- positive regulation of transcription elongation, DNA-dependent
- regulation of cyclin-dependent protein kinase activity
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- positive transcription elongation factor complex b
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- RNA polymerase II carboxy-terminal domain kinase activity
- cyclin-dependent protein kinase activity