NOP2 Gene Summary [Human]
Enables RNA binding activity. Involved in positive regulation of cell population proliferation; regulation of signal transduction by p53 class mediator; and ribosomal large subunit assembly. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | NOP2 |
| Official Name | NOP2 nucleolar protein [Source:HGNC Symbol;Acc:HGNC:7867] |
| Ensembl ID | ENSG00000111641 |
| Bio databases IDs | |
| Aliases | NOP2 nucleolar protein, NOP2/Sun domain family, member 1 |
| Synonyms | A530002O17, NOL1, NOP120, NOP2 nucleolar protein, NSUN1, p120 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NOP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- rRNA (cytosine-C5-967)-methyltransferase
- NOL1/NOP2/sun family putative RNA methylase
- N-terminal domain of 16S rRNA methyltransferase RsmF
- 16S rRNA methyltransferase RsmB/F
- enzyme
- protein binding
- AdoMet_MTases
- P120R (NUC006) repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
role in cell
- proliferation
- expression in
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NOP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maturation of LSU-rRNA
- rRNA base methylation
- ribosomal large subunit biogenesis
- positive regulation of cell proliferation
- rRNA processing
- ribosomal large subunit assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- rRNA (cytosine-C5-)-methyltransferase activity
- RNA binding
- protein binding