IL18R1 Gene Summary [Human]
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Details
| Type | Protein Coding |
| Official Symbol | IL18R1 |
| Official Name | interleukin 18 receptor 1 [Source:HGNC Symbol;Acc:HGNC:5988] |
| Ensembl ID | ENSG00000115604 |
| Bio databases IDs | |
| Aliases | interleukin 18 receptor 1 |
| Synonyms | CD218a, CDw218a, IL-18R, IL18RA, IL-18R-alpha, IL-18R-α, IL1R5, IL1RP, IL1RRP, interleukin 18 receptor 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IL18R1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- interleukin-18 binding
- interleukin-18 receptor
- signaling receptor activity
- cytoplasmic domain
- immunoglobulin domain
- Immunoglobulin like
- SEFIR domain
- protein binding
- TIR domain
- transmembrane receptor
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the IL18R1 gene in human plays a role, providing insight into its function and relevance in health or disease.
- FAK Signaling
- Glucocorticoid Receptor Signaling
- Natural Killer Cell Signaling
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- STAT3 Pathway
- T Helper Cell Differentiation
- Th1 and Th2 Activation Pathway
- Th1 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- septic shock
- experimental autoimmune encephalomyelitis
- atopic dermatitis
- anemia
- colorectal cancer
- allergy
- endometriosis
- inflammatory bowel disease
- pervasive developmental disorder
role in cell
- binding
- activation in
- expression in
- differentiation
- proliferation
- production in
- migration
- activation
- inflammation
- activity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- intracellular space
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IL18R1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- T-helper 1 cell differentiation
- inflammatory response
- immune response
- signal transduction
- positive regulation of interferon-gamma production
- natural killer cell activation
- positive regulation of T-helper 1 cell cytokine production
- positive regulation of NF-kappaB transcription factor activity
- interleukin-18-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- interleukin-18 receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- interleukin-18 receptor activity
- NAD+ nucleosidase activity
- protein binding
- signaling receptor activity
- interleukin-1 receptor activity
- interleukin-18 binding