TGFBR3 Gene Summary [Human]
This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | TGFBR3 |
| Official Name | transforming growth factor beta receptor 3 [Source:HGNC Symbol;Acc:HGNC:11774] |
| Ensembl ID | ENSG00000069702 |
| Bio databases IDs | |
| Aliases | transforming growth factor beta receptor 3, betaglycan proteoglycan |
| Synonyms | 1110036H20RIK, AU015626, betaglycan, BGCAN, TBRIII, Tgf beta Receptor 3, Tgf Beta Type 3 Receptor, TGFR-3, Tgf β Receptor 3, Tgf β Type 3 Receptor, Tgf-β type iii receptor, transforming growth factor beta receptor 3, transforming growth factor, beta receptor III, transforming growth factor β receptor 3, transforming growth factor, β receptor III |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TGFBR3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- SMAD binding
- punt binding
- cytokine binding
- ectodomain
- activin binding
- protein binding
- TGFbeta binding
- glycosaminoglycan binding
- PDZ-domain binding
- kinase
- transforming growth factor-beta receptor
- Zona pellucida-like domain
- cytoplasmic domain
- Zona pellucida (ZP) domain
- fibroblast growth factor binding
- transforming growth factor-beta receptor binding
- glycosaminoglycan attachment site
- cytosolic tail domain
- heparin binding
- transmembrane receptor
- coreceptor
Pathways
Biological processes and signaling networks where the TGFBR3 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Cellular Effects of Sildenafil (Viagra)
- CREB Signaling in Neurons
- Epithelial Adherens Junction Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- FAK Signaling
- Neuroinflammation Signaling Pathway
- NF-κB Signaling
- PPARα/RXRα Activation
- PTEN Signaling
- RAR Activation
- Role of Tissue Factor in Cancer
- Sertoli Cell-Sertoli Cell Junction Signaling
- STAT3 Pathway
- Th1 and Th2 Activation Pathway
- Th2 Pathway
- Transcriptional Regulatory Network in Embryonic Stem Cells
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- multiple sclerosis
- non-insulin-dependent diabetes mellitus
- migraines
- neoplasia
- neutropenia
- metastasis
- renal clear cell adenocarcinoma
- tumorigenesis
- septic shock
- granulosa cell tumor
role in cell
- expression in
- apoptosis
- growth
- phosphorylation in
- proliferation
- production in
- epithelial-mesenchymal transition
- migration
- invasion by
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Extracellular Space
- cellular membrane
- Nucleus
- Endoplasmic Reticulum
- granules
- cytosol
- plasma membrane extracellular face
- basolateral membrane
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TGFBR3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cardiac muscle cell proliferation
- response to prostaglandin E stimulus
- ventricular cardiac muscle tissue morphogenesis
- muscular septum morphogenesis
- transforming growth factor beta receptor signaling pathway
- outflow tract morphogenesis
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of cell migration involved in sprouting angiogenesis
- heart trabecula formation
- heart morphogenesis
- immune response
- response to hypoxia
- liver development
- BMP signaling pathway
- positive regulation of SMAD protein import into nucleus
- cell migration
- intracellular signal transduction
- transforming growth factor beta receptor complex assembly
- negative regulation of SMAD protein import into nucleus
- heart trabecula morphogenesis
- cardiac epithelial to mesenchymal transition
- definitive erythrocyte differentiation
- vasculogenesis involved in coronary vascular morphogenesis
- cardiac muscle cell proliferation
- ventricular septum morphogenesis
- ventricular compact myocardium morphogenesis
- definitive hemopoiesis
- regulation of JNK cascade
- regulation of ERK1 and ERK2 cascade
- positive regulation of gene expression
- negative regulation of epithelial cell proliferation
- epicardium-derived cardiac fibroblast cell development
- response to luteinizing hormone stimulus
- epithelial to mesenchymal transition
- organ regeneration
- response to follicle-stimulating hormone stimulus
- regulation of transforming growth factor beta receptor signaling pathway
- negative regulation of cell migration
- negative regulation of transforming growth factor beta receptor signaling pathway
- positive regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- inhibin-betaglycan-ActRII complex
- external side of plasma membrane
- receptor complex
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- BMP binding
- coreceptor activity
- transforming growth factor beta receptor binding
- transforming growth factor beta-activated receptor activity
- heparin binding
- type II transforming growth factor beta receptor binding
- transforming growth factor beta binding
- activin binding
- protein binding
- transmembrane signaling receptor activity
- SMAD binding
- glycosaminoglycan binding
- transforming growth factor beta receptor activity, type III
- PDZ domain binding
- fibroblast growth factor binding