PDS5B Gene Summary [Human]
This gene encodes a protein that interacts with the conserved protein complex termed cohesin. The cohesin complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. [provided by RefSeq, Jul 2015]
Details
| Type | Protein Coding |
| Official Symbol | PDS5B |
| Official Name | PDS5 cohesin associated factor B [Source:HGNC Symbol;Acc:HGNC:20418] |
| Ensembl ID | ENSG00000083642 |
| Bio databases IDs | |
| Aliases | PDS5 cohesin associated factor B |
| Synonyms | APRIN, AS3, CG008, mKIAA0979, NEWGENE 1321969, PDS5 cohesin associated factor B, Tg(Wap-ERBB2)229Wzw, WAP-Her-2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PDS5B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Sister chromatid cohesion protein PDS5 protein
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatitis
- cyanosis
- lung carcinoma
- lung carcinoma process
- asthma
- breast carcinoma
- uterine leiomyoma
- leiomyomatosis
- lung squamous cell carcinoma
- squamous cell lung cancer
role in cell
- differentiation
- proliferation
- expression in
- acetylation in
- number
- association
- aneuploidy
- abnormal morphology
- upregulation in
- induction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- chromosome
- nucleoplasm
- centromeres
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PDS5B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- cell proliferation
- DNA repair
- negative regulation of cell proliferation
- mitotic sister chromatid cohesion
- regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- chromosome
- chromosome, centromeric region
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding