TGIF2 Gene Summary [Human]
The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene. [provided by RefSeq, Dec 2010]
Details
| Type | Protein Coding |
| Official Symbol | TGIF2 |
| Official Name | TGFB induced factor homeobox 2 [Source:HGNC Symbol;Acc:HGNC:15764] |
| Ensembl ID | ENSG00000118707 |
| Bio databases IDs | |
| Aliases | TGFB induced factor homeobox 2 |
| Synonyms | 4921501K24, 5730599O09Rik, RGD1560115, RGD1564927, TGFB-induced factor homeobox 2, Tgif2l1, Tgif2l2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TGIF2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- sequence-specific DNA binding
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon neoplasm
- colorectal neoplasia
- primary antiphospholipid antibody syndrome
role in cell
- proliferation
- expression in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- centrosome
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TGIF2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of gastrulation
- amacrine cell differentiation
- regulation of transcription, DNA-dependent
- nodal signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity