KDM4B Gene Summary [Human]
Enables histone H3-methyl-lysine-36 demethylase activity and histone H3-methyl-lysine-9 demethylase activity. Involved in histone H3-K36 demethylation and histone H3-K9 demethylation. Located in cytosol and nucleoplasm. Implicated in autosomal dominant non-syndromic intellectual disability; breast cancer; colorectal cancer; malignant peripheral nerve sheath tumor; and stomach cancer. Biomarker of several diseases, including alopecia areata; lung cancer; medulloblastoma; prostate cancer; and stomach cancer. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | KDM4B |
| Official Name | lysine demethylase 4B [Source:HGNC Symbol;Acc:HGNC:29136] |
| Ensembl ID | ENSG00000127663 |
| Bio databases IDs | |
| Aliases | lysine demethylase 4B, tudor domain containing 14B |
| Synonyms | 4732474L06RIK, JMJD2B, lysine demethylase 4B, lysine (K)-specific demethylase 4B, MRD65, TDRD14B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KDM4B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- jmjN domain
- Lamin-B receptor of TUDOR domain
- catalytic domain
- 2-oxoglutarate:oxygen oxidoreductase
- enzyme
- RmlC-like cupin superfamily
- PHD-finger
- PHD-like zinc-binding domain
- PHD finger superfamily
- Tudor domain superfamily
- histone demethylase activity
- PHD-zinc-finger like domain
- Jumonji domain-containing protein 2A Tudor domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- breast cancer
- cancer
- systemic lupus erythematosus
- neoplasia
- hypertension
- restless legs syndrome
- autosomal dominant intellectual developmental disorder type 65
- Alzheimer disease
- organismal death
role in cell
- expression in
- migration
- invasion by
- autophagy in
- proliferation
- survival
- phosphorylation in
- trimethylation in
- apoptosis
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KDM4B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- regulation of gene expression
- brain development
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- histone demethylase activity (H3-K9 specific)
- histone demethylase activity
- histone demethylase activity (H3-K36 specific)