FGD3 Gene Summary [Human]
Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in several processes, including filopodium assembly; regulation of GTPase activity; and regulation of cell shape. Predicted to be located in Golgi apparatus; lamellipodium; and ruffle. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | FGD3 |
| Official Name | FYVE, RhoGEF and PH domain containing 3 [Source:HGNC Symbol;Acc:HGNC:16027] |
| Ensembl ID | ENSG00000127084 |
| Bio databases IDs | |
| Aliases | FYVE, RhoGEF and PH domain containing 3 |
| Synonyms | 5830461L01RIK, FYVE, RhoGEF and PH domain containing 3, ZFYVE5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FGD3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FYVE domain like superfamily
- FYVE zinc finger
- RhoGEF
- Protein present in Fab1, YOTB, Vac1, and EEA1
- guanyl-nucleotide exchange factor
- PH domain
- enzyme binding
- PHD finger superfamily
- Pleckstrin homology-like domain
- RhoGEF domain
Pathways
Biological processes and signaling networks where the FGD3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- metastasis
- breast cancer
- epithelial cancer
- epithelial neoplasia
- neoplasia
- organismal death
- pancreatic cancer
- pancreatic epithelial cancer
- epithelial cancer in situ
regulated by
- beta-estradiol
role in cell
- expression in
- proliferation
- migration
- assembly
- invasion by
- stimulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ruffle
- Golgi Apparatus
- cytosol
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FGD3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- cytoskeleton organization
- regulation of small GTPase mediated signal transduction
- regulation of GTPase activity
- actin cytoskeleton organization
- filopodium assembly
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- cytoplasm
- ruffle
- cytosol
- Golgi apparatus
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- guanyl-nucleotide exchange factor activity
- small GTPase binding