MTUS1 Gene Summary [Human]
This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways. [provided by RefSeq, Jul 2008]
Details
| Type | Retained Intron |
| Official Symbol | MTUS1 |
| Official Name | microtubule associated scaffold protein 1 [Source:HGNC Symbol;Acc:HGNC:29789] |
| Ensembl ID | ENSG00000129422 |
| Bio databases IDs | |
| Aliases | microtubule associated scaffold protein 1, AT2 receptor-interacting protein, AT2R binding protein, mitochondrial tumor suppressor gene 1 |
| Synonyms | AI481402, ATBP, ATBP135, ATIP, ATIP1, Atip3b, ATIP4, B430010I23RIK, B430305I03Rik, Cctsg1-440, ICIS, LOC100911065, MD44, microtubule associated scaffold protein 1, mitochondrial tumor suppressor 1, mitochondrial tumour suppressor 1, mKIAA1288, MP44, MTSG1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MTUS1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WTAP/Mum2p family
- Autophagy protein 16 (ATG16)
- Uncharacterized conserved protein H4 (DUF2046)
- CCDC144C protein coiled-coil region
- K-box region
- Snf7
- Laminin Domain I
- Tropomyosin
- Myosin-like coiled-coil protein
- SPEC
- Crescentin protein
- polo kinase kinase
- TPR/MLP1/MLP2-like protein
- PspA/IM30 family
- Tropomyosin like
- ALIX V-shaped domain binding to HIV
- Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
- SWI5-dependent HO expression protein 3
- protein binding
- Domain of unknown function (DUF4686)
- Mechanosensitive ion channel porin domain
- flagellar export protein FliJ
- Trichohyalin-plectin-homology domain
- Transforming acidic coiled-coil-containing protein (TACC), C-terminal
- Growth-arrest specific micro-tubule binding
- Intermediate filament protein
- Apolipoprotein A1/A4/E domain
- JNK_SAPK-associated protein-1
- Domain of unknown function (DUF4200)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- pancreatic neoplasia
- metastasis
- organismal death
- lung adenocarcinoma
- lung adenocarcinoma formation
- glaucoma
- respiratory disorder
- pancreatic neoplasm
- deep vein thrombosis
role in cell
- proliferation
- expression in
- migration
- apoptosis
- cell cycle progression
- invasion
- motility
- chemotaxis by
- phosphorylation in
- directional motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- microtubule cytoskeleton
- Cytoplasm
- Mitochondria
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MTUS1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of macrophage chemotaxis
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- microtubule cytoskeleton
- extracellular space
- cytoplasm
- mitochondrion
- spindle
- Golgi apparatus
- nucleolus
- plasma membrane
- microtubule
Molecular Function
What the gene product does at the molecular level
- microtubule binding