Mtus1 Gene Summary [Mouse]
Predicted to enable microtubule binding activity. Acts upstream of or within regulation of macrophage chemotaxis. Located in cytoplasm. Is expressed in several structures, including extraembryonic component; eye; genitourinary system; heart; and nervous system. Orthologous to human MTUS1 (microtubule associated scaffold protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mtus1 |
| Official Name | mitochondrial tumor suppressor 1 [Source:MGI Symbol;Acc:MGI:2142572] |
| Ensembl ID | ENSMUSG00000045636 |
| Bio databases IDs | |
| Aliases | mitochondrial tumor suppressor 1 |
| Synonyms | AI481402, ATBP, ATBP135, ATIP, ATIP1, Atip3b, ATIP4, B430010I23RIK, B430305I03Rik, Cctsg1-440, ICIS, LOC100911065, MD44, microtubule associated scaffold protein 1, mitochondrial tumor suppressor 1, mitochondrial tumour suppressor 1, mKIAA1288, MP44, MTSG1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mtus1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WTAP/Mum2p family
- Autophagy protein 16 (ATG16)
- Uncharacterized conserved protein H4 (DUF2046)
- CCDC144C protein coiled-coil region
- K-box region
- Snf7
- Laminin Domain I
- Tropomyosin
- Myosin-like coiled-coil protein
- SPEC
- Crescentin protein
- polo kinase kinase
- TPR/MLP1/MLP2-like protein
- PspA/IM30 family
- Tropomyosin like
- ALIX V-shaped domain binding to HIV
- Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
- SWI5-dependent HO expression protein 3
- protein binding
- Domain of unknown function (DUF4686)
- Mechanosensitive ion channel porin domain
- flagellar export protein FliJ
- Trichohyalin-plectin-homology domain
- Transforming acidic coiled-coil-containing protein (TACC), C-terminal
- Growth-arrest specific micro-tubule binding
- Intermediate filament protein
- Apolipoprotein A1/A4/E domain
- JNK_SAPK-associated protein-1
- Domain of unknown function (DUF4200)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- pancreatic neoplasia
- metastasis
- organismal death
- lung adenocarcinoma
- lung adenocarcinoma formation
- glaucoma
- respiratory disorder
- pancreatic neoplasm
- deep vein thrombosis
role in cell
- proliferation
- expression in
- migration
- apoptosis
- cell cycle progression
- invasion
- motility
- chemotaxis by
- phosphorylation in
- directional motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- microtubule cytoskeleton
- Cytoplasm
- Mitochondria
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mtus1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of macrophage chemotaxis
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- microtubule cytoskeleton
- extracellular space
- cytoplasm
- mitochondrion
- spindle
- Golgi apparatus
- nucleolus
- plasma membrane
- microtubule
Molecular Function
What the gene product does at the molecular level
- microtubule binding