NEDD8 Gene Summary [Human]
Enables ubiquitin protein ligase binding activity. Acts upstream of or within protein neddylation. Located in cytosol and nucleoplasm. Biomarker of Parkinson's disease and malignant astrocytoma. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | NEDD8 |
| Official Name | NEDD8 ubiquitin like modifier [Source:HGNC Symbol;Acc:HGNC:7732] |
| Ensembl ID | ENSG00000129559 |
| Bio databases IDs | |
| Aliases | NEDD8 ubiquitin like modifier |
| Synonyms | CDK8, NEDD8 ubiquitin like modifier, neural precursor cell expressed, developmentally down-regulated gene 8, Rub1, Similar to nedd8 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NEDD8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin family
- ubiquitin protein ligase binding
- Ubl1_cv_Nsp3_N-like
- Ubiquitin homologues
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the NEDD8 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- epithelial cancer
- cancer
- esophageal squamous cell carcinoma
- breast cancer
- Alzheimer disease
- organismal death
- aortic valve calcification
- esophageal squamous cell cancer
- prostatic carcinoma
role in cell
- phosphorylation in
- expression in
- transactivation in
- production in
- accumulation in
- activation in
- cell death
- proliferation
- binding in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- glutaminergic synapse
- Cytoplasm
- postsynaptic region
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NEDD8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- proteolysis
- regulation of proteolysis
- protein localization
- protein neddylation
- anatomical structure morphogenesis
- modification-dependent protein catabolic process
- protein ubiquitination
- regulation of transcription from RNA polymerase II promoter
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin protein ligase binding
- protein binding
- protein tag