RNF128 Gene Summary [Human]
The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | RNF128 |
| Official Name | ring finger protein 128 [Source:HGNC Symbol;Acc:HGNC:21153] |
| Ensembl ID | ENSG00000133135 |
| Bio databases IDs | |
| Aliases | ring finger protein 128 |
| Synonyms | 1300002C13Rik, GRAIL, Greul1, LOC100503383, LOC108348295, LOC315910, RGD1566282, ring finger protein 128 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RNF128 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- cell penetrating signal sequence
- ubiquitin protein ligase activity
- enzyme
- Ring finger domain
- protein binding
- RING-like zinc finger
- RING-type zinc-finger
- PA
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- transmembrane domain
- PHD finger superfamily
- RING-H2 zinc finger domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- alcoholic pancreatitis
- acute pancreatitis
- autoimmune disease
- dysferlinopathy
- non-small cell lung carcinoma
- non-small cell lung cancer
role in cell
- expression in
- phosphorylation in
- proliferation
- function
- ubiquitination in
- suppression
- anergy
- conversion
- conjugation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- recycling endosomes
- late endosomes
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RNF128 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein stability
- negative regulation of cytokine production
- protein ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytoskeleton
- cytoplasm
- membrane
- late endosome
- cytosol
- endoplasmic reticulum
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding