Dtx1 Gene Summary [Mouse]
Predicted to enable Notch binding activity; ubiquitin protein ligase activity; and ubiquitin protein ligase binding activity. Acts upstream of or within several processes, including Notch signaling pathway; cellular response to leukemia inhibitory factor; and negative regulation of T cell differentiation. Predicted to be located in cytosol and nuclear body. Predicted to be active in nucleoplasm. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Orthologous to human DTX1 (deltex E3 ubiquitin ligase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dtx1 |
| Official Name | deltex 1, E3 ubiquitin ligase [Source:MGI Symbol;Acc:MGI:1352744] |
| Ensembl ID | ENSMUSG00000029603 |
| Bio databases IDs | |
| Aliases | deltex 1, E3 ubiquitin ligase |
| Synonyms | Deltex 1, deltex 1, E3 ubiquitin ligase, deltex E3 ubiquitin ligase 1, Fxit1, hDx-1, mKIAA4160, RNF140 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dtx1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- Domain in Deltex and TRIP12 homologues
- transcription regulator
- transcription co-activator
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- WWE domain
- protein binding
- Domain found at the C-terminus of deltex-like
- notch binding
Pathways
Biological processes and signaling networks where the Dtx1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperplasia
- COVID-19
- lung adenocarcinoma formation
- breast cancer
- splenic marginal zone B-cell lymphoma
- splenic cancer
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- ZMYM2-FGFR1 induced stem cell leukemia lymphoma syndrome
- Sézary syndrome
role in cell
- proliferation
- activation
- phosphorylation in
- expression in
- migration
- apoptosis
- differentiation
- number
- function
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- membrane surface
- cytosol
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dtx1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- T cell differentiation
- negative regulation of T cell differentiation
- Notch signaling pathway
- transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- regulation of Notch signaling pathway
- negative regulation of neuron differentiation
- transcription from RNA polymerase II promoter
- cell surface receptor signaling pathway
- glial cell differentiation
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nuclear body
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- ubiquitin protein ligase binding
- protein binding
- transcription coactivator activity
- Notch binding
- SH3 domain binding