USP27X
USP27X Gene Summary
This gene encodes a member of the peptidase protein family. The encoded protein functions as a deubiquitinase that is involved in upregulation of the pro-apoptotic Bim protein. This protein may act as a tumor suppressor by increasing levels of Bim to counteract anti-apoptotic signals in cancer cells. Mutations in this gene have been associated with X-linked cognitive disability. [provided by RefSeq, Dec 2016]
Details
| Type | Protein Coding |
| Official Symbol | USP27X |
| Official Name | ubiquitin specific peptidase 27 X-linked [Source:HGNC Symbol;Acc:HGNC:13486] |
| Ensembl ID | ENSG00000273820 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 27 X-linked |
| Synonyms | MRX105,RGD1564628,Sfc11,ubiquitin specific peptidase 27, X chromosome,ubiquitin specific peptidase 27 X-linked,ubiquitin specific peptidase 27, X-linked,USP22L,USP27,Usp27x-ps1,XLID105 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cysteine endopeptidase
- peptidase
- ubiquitin-specific protease
- Ubiquitin carboxyl-terminal hydrolase
- protein binding
- Peptidase_C19
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the USP27X gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- SH3KBP1
- BCL2L11
- TAF9B
- MYC
- CCNE1
- MDM2
- NOTCH1
- RIPK1
- DTX1
- ATXN7L3
disease
- metastasis
- neoplasia
- epithelial cancer
- liver cancer
- X-linked mental retardation type 105
- X-linked mental retardation
- hepatocellular carcinoma
- neurodevelopmental disorder
- mental retardation
regulated by
- GSK3B
- EGF
- TCF7
- lithium chloride
- LEF1
- PIM2
- 5-fluorouracil
- IRF2BP1
regulates
- MYC
- HK2
- IRF3
- TBK1
- IFNB1
- CGAS
- cyclin E
- TRIM24
- SETD3
- CBX2
role in cell
- proliferation
- phosphorylation in
- expression in
- apoptosis
- migration
- production in
- cell viability
- colony formation by
- binding in
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the USP27X gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- protein deubiquitination
- innate immune response
- proteolysis
- positive regulation of apoptotic process
- positive regulation of type I interferon-mediated signaling pathway
- defense response to virus
- protein stabilization
- protein K48-linked deubiquitination
- protein K63-linked deubiquitination
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- cytosol
MOLECULAR FUNCTION
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- cysteine-type endopeptidase activity