TRAFD1 Gene Summary [Human]
The innate immune system confers host defense against viral and microbial infection, and TRAFD1 is a negative feedback regulator that controls excessive immune responses (Sanada et al., 2008 [PubMed 18849341]).[supplied by OMIM, Dec 2009]
Details
| Type | Retained Intron |
| Official Symbol | TRAFD1 |
| Official Name | TRAF-type zinc finger domain containing 1 [Source:HGNC Symbol;Acc:HGNC:24808] |
| Ensembl ID | ENSG00000135148 |
| Bio databases IDs | |
| Aliases | TRAF-type zinc finger domain containing 1 |
| Synonyms | 1110008K06Rik, FLN29, TRAF-type zinc finger domain containing 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRAFD1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- zinc finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- skin cancer
- septic shock
- gout
- T-cell non-Hodgkin disease
- endotoxin shock response
- skin basal cell carcinoma
- basal cell skin cancer
- cutaneous T-cell lymphoma
- mature T-cell neoplasia
role in cell
- production in
- expression in
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRAFD1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of innate immune response
Cellular Component
Where in the cell the gene product is active
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding