Trafd1 Gene Summary [Mouse]
Predicted to enable zinc ion binding activity. Involved in negative regulation of innate immune response. Predicted to be active in mitochondrion. Is expressed in central nervous system and neural retina. Orthologous to human TRAFD1 (TRAF-type zinc finger domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Trafd1 |
| Official Name | TRAF type zinc finger domain containing 1 [Source:MGI Symbol;Acc:MGI:1923551] |
| Ensembl ID | ENSMUSG00000042726 |
| Bio databases IDs | |
| Aliases | TRAF type zinc finger domain containing 1 |
| Synonyms | 1110008K06Rik, FLN29, TRAF-type zinc finger domain containing 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trafd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- zinc finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- skin cancer
- septic shock
- gout
- T-cell non-Hodgkin disease
- endotoxin shock response
- skin basal cell carcinoma
- basal cell skin cancer
- cutaneous T-cell lymphoma
- mature T-cell neoplasia
role in cell
- production in
- expression in
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trafd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of innate immune response
Cellular Component
Where in the cell the gene product is active
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding