PPP1R1A Gene Summary [Human]
Predicted to enable protein serine/threonine phosphatase inhibitor activity. Predicted to be involved in intracellular signal transduction. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PPP1R1A |
| Official Name | protein phosphatase 1 regulatory inhibitor subunit 1A [Source:HGNC Symbol;Acc:HGNC:9286] |
| Ensembl ID | ENSG00000135447 |
| Bio databases IDs | |
| Aliases | protein phosphatase 1 regulatory inhibitor subunit 1A |
| Synonyms | 0610038N18Rik, I-1, IPP1, protein phosphatase 1 regulatory inhibitor subunit 1A, protein phosphatase 1, regulatory (inhibitor) subunit 1A, protein phosphatase 1, regulatory inhibitor subunit 1A, Protein phosphatase inhibitor 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPP1R1A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- type 1 serine/threonine specific protein phosphatase inhibitor
- phosphoprotein phosphatase
- phosphatase
- protein binding
- Protein phosphatase inhibitor 1/DARPP-32
Pathways
Biological processes and signaling networks where the PPP1R1A gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- amyotrophic lateral sclerosis
- ischemic cardiomyopathy
- dilated cardiomyopathy
- atrial fibrillation
role in cell
- activation
- growth
- long-term potentiation
- shortening
- meiosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPP1R1A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycogen metabolic process
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase inhibitor activity
- protein binding