FRMD6 Gene Summary [Human]
Predicted to be involved in actomyosin structure organization. Predicted to act upstream of or within apical constriction; cellular protein localization; and regulation of actin filament-based process. Predicted to be located in apical junction complex. Predicted to be active in cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | FRMD6 |
| Official Name | FERM domain containing 6 [Source:HGNC Symbol;Acc:HGNC:19839] |
| Ensembl ID | ENSG00000139926 |
| Bio databases IDs | |
| Aliases | FERM domain containing 6, expanded homolog |
| Synonyms | 2610019M19Rik, 4930488L10RIK, c14 5320, C14orf31, EX, EX1, FERM domain containing 6, LOC257646, Willin |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FRMD6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FERM central domain
- Band 4.1 homologues
- Ubl1_cv_Nsp3_N-like
- protein binding
- Pleckstrin homology-like domain
- FERM domain B-lobe
- FERM C-terminal PH-like domain
- FERM N-terminal domain
Pathways
Biological processes and signaling networks where the FRMD6 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- polycystic kidney disease
- mechanical hypersensitivity
role in cell
- accumulation in
- activation in
- proliferation
- expression in
- migration
- cell death
- colony formation
- growth
- cell cycle progression
- upregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- intercellular junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FRMD6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of hippo signaling cascade
- protein localization
- apical constriction
- regulation of actin filament-based process
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- cytoplasm
- apical junction complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding