ADAM21 Gene Summary [Human]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The expression of this gene expression is testis-specific. [provided by RefSeq, May 2011]

Details

Type
Protein Coding
Official Symbol
ADAM21
Official Name
ADAM metallopeptidase domain 21 [Source:HGNC Symbol;Acc:HGNC:200]
Ensembl ID
ENSG00000139985
Bio databases IDs NCBI: 8747 Ensembl: ENSG00000139985
Aliases ADAM metallopeptidase domain 21
Synonyms ADAM31, ADAM metallopeptidase domain 21
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ADAM21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Reprolysin family propeptide
  • metallopeptidase
  • ZnMc
  • ADAM cysteine-rich
  • Metallo-peptidase family M12B Reprolysin-like
  • peptidase
  • Disintegrin
  • Reprolysin (M12B) family zinc metalloprotease
  • protein binding

Pathways

Biological processes and signaling networks where the ADAM21 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cellular membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human ADAM21 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • male gonad development
  • proteolysis
  • single fertilization

Cellular Component

Where in the cell the gene product is active
  • external side of plasma membrane
  • neuronal cell body
  • plasma membrane
  • axon

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • metal ion binding
  • metalloendopeptidase activity
  • metallopeptidase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.