USP39
USP39 Gene Summary
Predicted to enable thiol-dependent deubiquitinase and zinc ion binding activity. Involved in spliceosomal complex assembly. Located in nucleoplasm. Part of U4/U6 x U5 tri-snRNP complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | USP39 |
| Official Name | ubiquitin specific peptidase 39 [Source:HGNC Symbol;Acc:HGNC:20071] |
| Ensembl ID | ENSG00000168883 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 39, snRNP assembly defective 1 homolog (S. cerevisiae), small nuclear ribonucleoprotein 65kDa (U4/U6.U5) |
| Synonyms | 65K,CGI-21,D6Wsu157e,HSPC332,SAD1,SNRNP65,ubiquitin specific peptidase 39 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zn-finger in ubiquitin-hydrolases and other protein
- peptidase
- Ubiquitin carboxyl-terminal hydrolase
- Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger
- protein binding
- Peptidase_C19
Pathways
Biological processes and signaling networks where the USP39 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- TOP1
- TP53
- SUMO3
- SAE1
- HNRNPU
- MDM2
- TRIM25
- LSM1
- CHEK2
- NUPR1
disease
- cervical squamous cell carcinoma
- gastric cancer
- acute myeloid leukemia
- organismal death
- neoplasia
- hepatic steatosis
- myocardial infarction
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- nonalcoholic steatohepatitis
regulated by
- fulvestrant
- RXRA
- RXRB
- SUMO2
- lipopolysaccharide
- AGRN
- tamoxifen
- SIRT7
- Major late
- MLN7243
regulates
- IL10
- IL6
- TNF
- VEGFA
- lipid
- TP53
- MYC
- SIRT7
- IL1B
- LAMP2
role in cell
- expression in
- proliferation
- phosphorylation in
- production in
- accumulation in
- growth
- migration
- cell viability
- formation
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- spliceosomes
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the USP39 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- cell division
- RNA splicing
- mRNA processing
- spliceosomal complex assembly
- nuclear mRNA splicing, via spliceosome
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- U4/U6 x U5 tri-snRNP complex
- spliceosomal complex
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- zinc ion binding
- protein binding