NLRC5 Gene Summary [Human]
This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways. [provided by RefSeq, Oct 2011]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | NLRC5 |
| Official Name | NLR family CARD domain containing 5 [Source:HGNC Symbol;Acc:HGNC:29933] |
| Ensembl ID | ENSG00000140853 |
| Bio databases IDs | |
| Aliases | NLR family CARD domain containing 5, nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 5, NOD-like receptor C5 |
| Synonyms | AI451557, CLR16.1, Cpne2, LOC100912184, LOC102553150, LOC102553241, LOC108348892, NLR family CARD domain containing 5, NLR family, CARD domain containing 5, NOD27, NOD4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NLRC5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NLRC4 helical domain HD2
- transcription regulator
- protein phosphatase 1 regulatory subunit 42
- nucleic acid binding
- walker type A motif
- Leucine rich repeat
- protein binding
- Leucine Rich repeats (2 copies)
- NACHT domain
- sequence-specific DNA binding
- effector domain
- Atypical caspase recruitment domain
- nucleotide-binding domain
- leucine-rich repeat
- double-stranded DNA binding
- Leucine rich repeat, ribonuclease inhibitor type
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Pathways
Biological processes and signaling networks where the NLRC5 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- multiple sclerosis
- systemic lupus erythematosus
- schizophrenia
- bipolar disorder
- survival
- metabolic syndrome X
- depressive disorder
- dextran sodium sulfate-induced colitis
- leukopenia
role in cell
- expression in
- production in
- phosphorylation in
- activation in
- quantity
- number
- binding in
- replication in
- activation
- M1 polarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- centrosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NLRC5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of kinase activity
- response to bacterium
- negative regulation of NF-kappaB transcription factor activity
- innate immune response
- positive regulation of type I interferon-mediated signaling pathway
- negative regulation of type I interferon-mediated signaling pathway
- defense response to virus
- positive regulation of MHC class I biosynthetic process
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of interferon-gamma-mediated signaling pathway
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding