TM4SF5 Gene Summary [Human]
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells. [provided by RefSeq, Jul 2008]
Details
| Type | Retained Intron |
| Official Symbol | TM4SF5 |
| Official Name | transmembrane 4 L six family member 5 [Source:HGNC Symbol;Acc:HGNC:11857] |
| Ensembl ID | ENSG00000142484 |
| Bio databases IDs | |
| Aliases | transmembrane 4 L six family member 5 |
| Synonyms | 2010003F10RIK, transmembrane 4 L six family member 5, transmembrane 4 superfamily member 5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TM4SF5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- L6 membrane protein
- protein binding
- amino acid binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- tumorigenesis
- metastasis
- cancer
- coronary artery disease
role in cell
- expression in
- migration
- glycolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- lysosome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TM4SF5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of G1/S transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- membrane
- lysosomal membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- arginine binding
- protein binding