DYRK3 Gene Summary [Human]
This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | DYRK3 |
| Official Name | dual specificity tyrosine phosphorylation regulated kinase 3 [Source:HGNC Symbol;Acc:HGNC:3094] |
| Ensembl ID | ENSG00000143479 |
| Bio databases IDs | |
| Aliases | dual specificity tyrosine phosphorylation regulated kinase 3, regulatory erythroid kinase, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 5, protein kinase Dyrk3 |
| Synonyms | dual-specificity tyrosine phosphorylation regulated kinase 3, DYRK5, hYAK3-2, RED, REDK |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DYRK3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- protein threonine/tyrosine kinase
- Protein tyrosine and serine/threonine kinase
- ATP binding
- protein binding
- protein-tyrosine kinase
- magnesium ion binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the DYRK3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glioblastoma
- glioblastoma cancer
- migraines
- insulin-dependent diabetes mellitus
role in cell
- growth
- phosphorylation in
- apoptosis
- differentiation
- colony formation
- number
- survival
- cell survival
- migration
- disassembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- centrosome
- cytosol
- nucleoplasm
- nuclear speckles
- stress granule
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DYRK3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- negative regulation of DNA damage response, signal transduction by p53 class mediator
- erythrocyte differentiation
- stress granule disassembly
- nuclear speck organization
- negative regulation of apoptotic process
- regulation of cellular response to stress
- protein phosphorylation
- peptidyl-serine phosphorylation
- peptidyl-threonine phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- pericentriolar material
- cytoplasmic stress granule
- cytoskeleton
- cytoplasm
- intracellular membrane-bounded organelle
- nuclear speck
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- protein tyrosine kinase activity
- protein serine/threonine/tyrosine kinase activity
- protein kinase activity
- protein serine/threonine kinase activity