SRD5A1 Gene Summary [Human]
Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).[supplied by OMIM, Mar 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | SRD5A1 |
| Official Name | steroid 5 alpha-reductase 1 [Source:HGNC Symbol;Acc:HGNC:11284] |
| Ensembl ID | ENSG00000145545 |
| Bio databases IDs | |
| Aliases | steroid 5 alpha-reductase 1, 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
| Synonyms | 0610031P22RIK, 3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1, 3-oxo-5 α-steroid δ 4-dehydrogenase α 1, 4930435F02Rik, 5alpha-R1, 5 Alpha Reductase, 5alpha-reductase Type1, 5 α Reductase, S5AR 1, Steroid 5 Alpha Reductase, steroid 5 alpha-reductase 1, Steroid 5 α Reductase, steroid 5 α-reductase 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SRD5A1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NADPH binding
- electron carrier
- 3-oxo-5alpha-steroid 4-dehydrogenase
- 3-oxo-5-alpha-steroid 4-dehydrogenase
- binding protein
- enzyme
- protein binding
- Isoprenylcysteine carboxyl methyltransferase (ICMT) family
Pathways
Biological processes and signaling networks where the SRD5A1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- HIV infection
- liver cancer
- epithelial cancer
- hepatic steatosis
- prostatic hyperplasia
- male pattern hair loss
- prostate cancer
- colon cancer
- nonalcoholic fatty liver disease
- benign prostatic hyperplasia
role in cell
- expression in
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- neurites
- microsomal membrane
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SRD5A1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to estrogen stimulus
- male gonad development
- hypothalamus development
- response to xenobiotic stimulus
- sex determination
- thalamus development
- bone development
- spinal cord development
- cellular response to insulin stimulus
- cellular response to testosterone stimulus
- cellular response to estradiol stimulus
- cellular response to epinephrine stimulus
- liver development
- female genitalia development
- progesterone metabolic process
- response to muscle activity
- serotonin metabolic process
- response to fungicide
- response to growth hormone stimulus
- hippocampus development
- cellular response to starvation
- cerebral cortex development
- steroid biosynthetic process
- androgen catabolic process
- pituitary gland development
- urogenital system development
- androgen biosynthetic process
- male genitalia development
- cellular response to growth factor stimulus
- cellular response to cAMP
- cell differentiation
- diterpenoid metabolic process
- response to follicle-stimulating hormone stimulus
- cellular response to dexamethasone stimulus
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- perinuclear region of cytoplasm
- cell body fiber
- neuronal cell body
Molecular Function
What the gene product does at the molecular level
- 3-oxo-5-alpha-steroid 4-dehydrogenase activity
- cholestenone 5-alpha-reductase activity
- electron carrier activity
- NADPH binding
- amide binding