NCAPG2 Gene Summary [Human]
This gene encodes a protein that belongs to the Condensin2nSMC family of proteins. The encoded protein is a regulatory subunit of the condensin II complex which, along with the condensin I complex, plays a role in chromosome assembly and segregation during mitosis. A similar protein in mouse is required for early development of the embryo. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | NCAPG2 |
| Official Name | non-SMC condensin II complex subunit G2 [Source:HGNC Symbol;Acc:HGNC:21904] |
| Ensembl ID | ENSG00000146918 |
| Bio databases IDs | |
| Aliases | non-SMC condensin II complex subunit G2 |
| Synonyms | 3KS, 5830426I05Rik, CAP-G2, FLJ20311, hCAP-G2, LUZP5, mCAP-G2, MTB, non-SMC condensin II complex subunit G2, non-SMC condensin II complex, subunit G2, RGD1308406 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NCAPG2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HEAT repeat
- histone binding
- Condensin II non structural maintenance of chromosomes subunit
- protein binding activity, bridging
- transcription factor binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- Khan-Khan-Katsanis syndrome
- prostate cancer
- small cell lung cancer
role in cell
- apoptosis
- expression in
- migration
- invasion by
- proliferation
- structure
- activity
- sphere formation by
- colony formation by
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromosome
- nucleoplasm
- nuclear speckles
- chromosomal arms
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NCAPG2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- positive regulation of chromosome segregation
- erythrocyte differentiation
- inner cell mass cell proliferation
- chromosome condensation
- mitotic sister chromatid segregation
- transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- membrane
- condensin complex
- condensed nuclear chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- methylated histone residue binding
- bHLH transcription factor binding