CYSLTR2 Gene Summary [Human]
The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CYSLTR2 |
| Official Name | cysteinyl leukotriene receptor 2 [Source:HGNC Symbol;Acc:HGNC:18274] |
| Ensembl ID | ENSG00000152207 |
| Bio databases IDs | |
| Aliases | cysteinyl leukotriene receptor 2 |
| Synonyms | 2300001H05Rik, Cltr2, CYSLT2, CYSLT2R, cysteinyl leukotriene receptor 2, GPCR21, HG57, hGPCR21, HPN321, KPG 011, LOC102547340, LOC684547, PSEC0146, RSBPT32 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CYSLTR2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- cysteinyl leukotriene receptor
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the CYSLTR2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- vascular leak syndrome
- neoplasia
- edema
- COVID-19
- insulin-dependent diabetes mellitus
- graft rejection
- seasonal allergic rhinitis
- asthma
- pain
- airway hyperresponsiveness
role in cell
- proliferation
- expression in
- activation in
- growth
- accumulation in
- activation
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- nuclear fraction
- Cytoplasm
- cell surface
- intracellular space
- cellular membrane
- Nucleus
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CYSLTR2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuropeptide signaling pathway
- immune response
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- leukotriene receptor activity
- cysteinyl leukotriene receptor activity
- G-protein coupled peptide receptor activity
- protein binding