AGPAT5 Gene Summary [Human]
This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. A pseudogene of this gene is present on the Y chromosome. [provided by RefSeq, Aug 2014]
Details
| Type | Protein Coding |
| Official Symbol | AGPAT5 |
| Official Name | 1-acylglycerol-3-phosphate O-acyltransferase 5 [Source:HGNC Symbol;Acc:HGNC:20886] |
| Ensembl ID | ENSG00000155189 |
| Bio databases IDs | |
| Aliases | 1-acylglycerol-3-phosphate O-acyltransferase 5, lysophosphatidic acid acyltransferase, epsilon |
| Synonyms | 1110013A05Rik, 1-acylglycerol-3-phosphate O-acyltransferase 5, 1AGPAT5, D8Ertd319e, FLJ11210, LPAATE, LPLAT5, RGD1306405 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AGPAT5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
- 1-acylglycerol-3-phosphate O-acyltransferase
- enzyme
- protein binding
- Acyltransferase
- Acyltransferase C-terminus
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- small cell lung cancer
- early onset hypertension
regulates
- adenosine triphosphate
- GCG
- phosphatidic acid
- acylglycerol
role in cell
- activation
- production in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Mitochondria
- endoplasmic reticulum membrane
- mitochondrial outer membrane
- nucleoli
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AGPAT5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acylglycerol metabolic process
- phospholipid biosynthetic process
- CDP-diacylglycerol biosynthetic process
- phosphatidylinositol acyl-chain remodeling
- hemopoietic progenitor cell differentiation
- phosphatidic acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- endoplasmic reticulum membrane
- mitochondrion
- endomembrane system
- endoplasmic reticulum
- nucleolus
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- 1-acylglycerol-3-phosphate O-acyltransferase activity
- transferase activity, transferring acyl groups
- protein binding