BATF Gene Summary [Human]
The protein encoded by this gene is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | BATF |
| Official Name | basic leucine zipper ATF-like transcription factor [Source:HGNC Symbol;Acc:HGNC:958] |
| Ensembl ID | ENSG00000156127 |
| Bio databases IDs | |
| Aliases | basic leucine zipper ATF-like transcription factor, activating transcription factor B, SF-HT-activated gene 2 |
| Synonyms | basic leucine zipper ATF-like transcription factor, basic leucine zipper transcription factor, ATF-like, BATF1, SFA-2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BATF often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- transcription factor binding domain
- nucleic acid binding
- double-stranded DNA binding
- Basic region leucine zipper
- protein binding
- sequence-specific DNA binding
- bZIP
- transcription factor activity
- basic region leucin zipper
Pathways
Biological processes and signaling networks where the BATF gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- inflammatory disorder
- pneumonitis
- idiopathic scoliosis
- colitis
- diabetic nephropathy
- Crohn disease
- exhaustion
- experimental autoimmune encephalomyelitis
- multiple sclerosis
- neonatal late-onset sepsis
role in cell
- expression in
- production in
- proliferation
- phosphorylation in
- differentiation
- binding in
- migration
- quantity
- number
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BATF gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- hemopoietic stem cell differentiation
- response to DNA damage stimulus
- positive regulation of transcription from RNA polymerase II promoter
- lymphoid progenitor cell differentiation
- regulation of transcription from RNA polymerase II promoter
- defense response to protozoan
- regulation of T-helper 17 cell differentiation
- T-helper 2 cell differentiation
- myeloid dendritic cell differentiation
- T-helper 17 cell lineage commitment
- DNA damage response, signal transduction by p53 class mediator
- T-helper 17 cell differentiation
- positive regulation of cytokine production
- isotype switching
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity