MORC3 Gene Summary [Human]
This gene encodes a protein that localizes to the nuclear matrix and forms nuclear bodies via an ATP-dependent mechanism. The protein is predicted to have coiled-coil and zinc finger domains and has RNA binding activity. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2016]
Details
| Type | Retained Intron |
| Official Symbol | MORC3 |
| Official Name | MORC family CW-type zinc finger 3 [Source:HGNC Symbol;Acc:HGNC:23572] |
| Ensembl ID | ENSG00000159256 |
| Bio databases IDs | |
| Aliases | MORC family CW-type zinc finger 3 |
| Synonyms | 1110051N18Rik, D16Jhu32e, KIAA0136, microrchidia 3, MORC family CW-type zinc finger 3, NXP2, ZCW5, ZCWCC3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MORC3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- CW-type Zinc Finger
- Histidine kinase-like ATPase domain
- protein binding activity, bridging
- Clathrin-binding domain of Huntingtin-interacting protein 1
- protein binding
- Morc6 ribosomal protein S5 domain 2-like
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear foci
- nucleoplasm
- nuclear rim
- nuclear matrix
- PML nuclear bodies
- chromatin
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MORC3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of fibroblast proliferation
- post-embryonic development
- positive regulation of cellular senescence
- protein stabilization
- peptidyl-serine phosphorylation
- protein phosphorylation
- maintenance of protein location in nucleus
- negative regulation of interferon-beta production
Cellular Component
Where in the cell the gene product is active
- nucleus
- PML body
- nuclear matrix
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- DNA binding
- zinc ion binding
- RNA binding
- protein binding
- methylated histone residue binding
- protein binding, bridging