ALOX15
ALOX15 Gene Summary
This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on various polyunsaturated fatty acid substrates to generate various bioactive lipid mediators such as eicosanoids, hepoxilins, lipoxins, and other molecules. The encoded enzyme and its reaction products have been shown to regulate inflammation and immunity. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]
Details
| Type | Protein Coding |
| Official Symbol | ALOX15 |
| Official Name | arachidonate 15-lipoxygenase [Source:HGNC Symbol;Acc:HGNC:433] |
| Ensembl ID | ENSG00000161905 |
| Bio databases IDs | |
| Aliases | arachidonate 15-lipoxygenase |
| Synonyms | 12/15 LO,12-LOX,15LO,15-LOX,15-LOX-1,ARACHIDONATE 15-LIPOXYGENASE,LEUKOCYTE 12-LO,LEUKOCYTE-type 12-LO,Leukocyte Type 12-LOX,LOG15 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipoxygenase
- arachidonate 12-lipoxygenase
- phosphatidylinositol-4,5-bisphosphate binding
- PLAT
- arachidonate 15-lipoxygenase
- iron ion binding
- enzyme
- protein binding
- Lipoxygenase homology 2 (beta barrel) domain
Pathways
Biological processes and signaling networks where the ALOX15 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- HNRNPK
- PEBP1
- USP48
- MBNL1
- RAF1
- PCBP1
- STAT6
- TIMM29
- DDX19B
- PRKDC
disease
- Alzheimer disease
- Parkinson disease
- head and neck neoplasia
- epithelial cancer
- atherosclerosis
- asthma
- ductal carcinoma
- breast cancer
- nasal polyp
- lung adenocarcinoma
regulated by
- TNF
- IFNG
- genistein
- exisulind
- IL4
- EGF
- ALOX15
- NS-398
- PCBP1
- sulindac
regulates
- HAMP
- IL6
- NOS2
- PPARG
- TNF
- arachidonic acid
- IL1B
- RHOA
- lipid
- NOTCH3
role in cell
- expression in
- accumulation in
- phosphorylation in
- activation in
- proliferation
- production in
- apoptosis
- G1 phase
- binding in
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- lipid droplets
- cytosol
- cytoplasmic face of plasma membrane
- membrane processes
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the ALOX15 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- long-chain fatty acid biosynthetic process
- inflammatory response
- wound healing
- cellular response to calcium ion
- ossification
- hepoxilin biosynthetic process
- lipoxin A4 biosynthetic process
- positive regulation of cell-substrate adhesion
- arachidonic acid metabolic process
- regulation of peroxisome proliferator activated receptor signaling pathway
- bone mineralization
- lipid oxidation
- linoleic acid metabolic process
- apoptotic cell clearance
- negative regulation of adaptive immune response
- phosphatidylethanolamine biosynthetic process
- fatty acid oxidation
- lipoxygenase pathway
- positive regulation of actin filament polymerization
- lipid metabolic process
- positive regulation of ERK1 and ERK2 cascade
- regulation of inflammatory response
- cellular response to interleukin-13
- response to endoplasmic reticulum stress
CELLULAR COMPONENT
Where in the cell the gene product is active
- lipid particle
- membrane
- cytosol
- plasma membrane
- internal side of plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- phosphatidylinositol-4,5-bisphosphate binding
- protein binding
- iron ion binding
- arachidonate 15-lipoxygenase activity
- arachidonate 12-lipoxygenase activity
- lipoxygenase activity