GNG3 Gene Summary [Human]
Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The gamma subunit determines the specificity of which signaling pathways will be affected by this particular complex. The protein encoded by this gene represents the gamma subunit of both inhibitory and stimulatory complexes. [provided by RefSeq, Jan 2012]
Details
| Type | Protein Coding |
| Official Symbol | GNG3 |
| Official Name | G protein subunit gamma 3 [Source:HGNC Symbol;Acc:HGNC:4405] |
| Ensembl ID | ENSG00000162188 |
| Bio databases IDs | |
| Aliases | G protein subunit gamma 3, guanine nucleotide-binding protein gamma-3 subunit, NBP gamma-3 |
| Synonyms | G gamma3, G protein gamma 3, G protein subunit gamma 3, G protein subunit γ 3, G protein γ 3, Guanine nucleotide binding protein, gamma 3 subunit, guanine nucleotide binding protein (G protein), gamma 3, guanine nucleotide binding protein (G protein), γ 3, Guanine nucleotide binding protein, γ 3 subunit, HG3D |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GNG3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CAAX box
- GGL
- protein binding
- GGL domain
Pathways
Biological processes and signaling networks where the GNG3 gene in human plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- Androgen Signaling
- Antiproliferative Role of Somatostatin Receptor 2
- Apelin Endothelial Signaling Pathway
- Apelin Muscle Signaling Pathway
- Cardiac β-adrenergic Signaling
- CCR3 Signaling in Eosinophils
- CCR5 Signaling in Macrophages
- CXCR4 Signaling
- Endocannabinoid Developing Neuron Pathway
- Ephrin B Signaling
- Ephrin Receptor Signaling
- fMLP Signaling in Neutrophils
- G Beta Gamma Signaling
- Glutamate Receptor Signaling
- Gαq Signaling
- IL-1 Signaling
- IL-8 Signaling
- Molecular Mechanisms of Cancer
- P2Y Purinergic Receptor Signaling Pathway
- Protein Kinase A Signaling
- Relaxin Signaling
- RhoGDI Signaling
- Sperm Motility
- Thrombin Signaling
- α-Adrenergic Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- pituitary gland adenoma
- head and neck neuroendocrine neoplasia
- weight gain
- hereditary disorder
- Huntington disease
- seizures
- tonic-clonic seizure
- environmentally induced seizure
role in cell
- proliferation
- fragmentation in
- elevation in
- fragmentation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- growth cone
- synapse
- perikaryon
- dendrites
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GNG3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- dendrite
- heterotrimeric G-protein complex
- cell body
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- G-protein beta-subunit binding
- GTPase activity