KIF15 Gene Summary [Human]
Predicted to enable microtubule binding activity and microtubule motor activity. Predicted to be involved in microtubule-based movement. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | KIF15 |
| Official Name | kinesin family member 15 [Source:HGNC Symbol;Acc:HGNC:17273] |
| Ensembl ID | ENSG00000163808 |
| Bio databases IDs | |
| Aliases | kinesin family member 15 |
| Synonyms | 3110023M17Rik, 3930402I10Rik, b2b1117.1aClo, b2b1117.1Clo, BRDCS2, D330038N01, HKLP2, kinesin family member 15, KLP2, KNSL7, NY-BR-62 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KIF15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mitotic checkpoint protein
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- Myosin and Kinesin motor domain
- Hyaluronan mediated motility receptor N-terminal
- rad50
- Synaptonemal complex protein 1 (SCP-1)
- Myosin tail
- helix-rich Mycoplasma protein
- SWI5-dependent HO expression protein 3
- enzyme
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Kinesin motor, catalytic domain
- microtubule binding
- chromosome segregation protein SMC, common bacterial type
- RecF/RecN/SMC N terminal domain
- RIM-binding protein of the cytomatrix active zone
- Kinesin motor domain
- plus-end-directed kinesin ATPase
- motor protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- liver cancer
- organismal death
- major depression
- HER2 negative hormone receptor negative breast cancer
- colorectal cancer
- Braddock-Carey syndrome type 2
- bipolar disorder
- sepsis
- metabolic syndrome X
role in cell
- apoptosis
- expression in
- invasion by
- phosphorylation in
- growth
- binding in
- proliferation
- migration
- recycling in
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- centrosome
- cytosol
- chromosome
- spindle pole
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KIF15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- centrosome separation
- microtubule-based movement
- mitotic cell cycle
- spindle assembly involved in mitosis
Cellular Component
Where in the cell the gene product is active
- centrosome
- membrane
- spindle pole
- cytosol
- kinesin complex
- plus-end kinesin complex
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- microtubule motor activity
- protein binding
- plus-end-directed microtubule motor activity
- motor activity
- microtubule binding