SLBP Gene Summary [Human]
This gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop structure is essential for efficient processing but this structure also controls the transport, translation and stability of histone mRNAs. Expression of the protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SLBP |
| Official Name | stem-loop binding protein [Source:HGNC Symbol;Acc:HGNC:10904] |
| Ensembl ID | ENSG00000163950 |
| Bio databases IDs | |
| Aliases | stem-loop binding protein, histone binding protein |
| Synonyms | HBP, LOC682588, stem-loop binding protein, stem-loop histone mRNA binding protein |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLBP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA binding
- nuclear localization sequence
- protein binding
- Histone RNA hairpin-binding protein RNA-binding domain
- identical protein binding
- translation activation domain
- RNA-binding domain
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLBP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cap-dependent translational initiation
- histone mRNA 3'-end processing
- mRNA transport
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- histone pre-mRNA 3'end processing complex
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- RNA binding
- protein binding
- mRNA binding
- histone pre-mRNA DCP binding
- histone pre-mRNA stem-loop binding