MOAP1 Gene Summary [Human]
The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MOAP1 |
| Official Name | modulator of apoptosis 1 [Source:HGNC Symbol;Acc:HGNC:16658] |
| Ensembl ID | ENSG00000165943 |
| Bio databases IDs | |
| Aliases | modulator of apoptosis 1, paraneoplastic Ma antigen family member 4 |
| Synonyms | 9130023M10RIK, MAP-1, MmMOAP1, modulator of apoptosis 1, PNMA4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MOAP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- Bcl-2 homology 3 domain
- PNMA
- protein binding
- TNF-R1 binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- peripheral T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
role in cell
- quantity
- apoptosis
- interaction in
- transmembrane potential
- cell death
- assembly
- interaction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MOAP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagy
- positive regulation of release of cytochrome c from mitochondria
- positive regulation of apoptotic process
- positive regulation of autophagic vacuole assembly
- apoptotic signaling pathway
- regulation of apoptotic process
- DNA damage response, signal transduction resulting in induction of apoptosis
- extrinsic apoptotic signaling pathway in absence of ligand
- induction of apoptosis via death domain receptors
- protein insertion into mitochondrial membrane
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- cytosol
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin protein ligase binding