SENP8 Gene Summary [Human]
This gene encodes a cysteine protease that is a member of the sentrin-specific protease family. The encoded protein is involved in processing and deconjugation of the ubiquitin-like protein termed, neural precursor cell expressed developmentally downregulated 8. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
Details
| Type | Protein Coding |
| Official Symbol | SENP8 |
| Official Name | SUMO peptidase family member, NEDD8 specific [Source:HGNC Symbol;Acc:HGNC:22992] |
| Ensembl ID | ENSG00000166192 |
| Bio databases IDs | |
| Aliases | SUMO peptidase family member, NEDD8 specific, NEDD8-specific protease 1, sentrin/SUMO-specific protease SENP8, deneddylase 1 |
| Synonyms | 9130010J17Rik, DEN1, FKSG8, NEDP1, PRSC2, SUMO peptidase family member, NEDD8 specific |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SENP8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cysteine-type peptidase
- NEDD8-specific protease
- Ulp1 protease family, C-terminal catalytic domain
- peptidase
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SENP8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- protein deneddylation
- post-translational protein modification
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- NEDD8-specific protease activity
- cysteine-type peptidase activity