Senp8 Gene Summary [Mouse]
Predicted to enable cysteine-type peptidase activity and deNEDDylase activity. Predicted to be involved in protein deneddylation. Is expressed in testis. Orthologous to human SENP8 (SUMO peptidase family member, NEDD8 specific). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Senp8 |
| Official Name | SUMO/sentrin specific peptidase 8 [Source:MGI Symbol;Acc:MGI:1918849] |
| Ensembl ID | ENSMUSG00000051705 |
| Bio databases IDs | |
| Aliases | SUMO/sentrin specific peptidase 8 |
| Synonyms | 9130010J17Rik, DEN1, FKSG8, NEDP1, PRSC2, SUMO peptidase family member, NEDD8 specific |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Senp8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cysteine-type peptidase
- NEDD8-specific protease
- Ulp1 protease family, C-terminal catalytic domain
- peptidase
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Senp8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- protein deneddylation
- post-translational protein modification
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- NEDD8-specific protease activity
- cysteine-type peptidase activity